Bungarotoxin



Bungarotoxins. α-Bungarotoxin (α-BGT), β-Bungarotoxin (β-BGT), γ-Bungarotoxin (γ-BGT) and κ-Bungarotoxin (κ-BGT) are snake toxins from banded krait. α-BGT binds irreversibly to the acetylcholine receptor (AChR) causing paralysis and death. β-BGT binds  to the presynaptic terminal causing release of acetylcholine. The images at the left and at the right correspond to one representative Bungarotoxin, i.e. the crystal structure of α-Bungarotoxin (2abx).

Bungarotoxin
2abx – α-BGT

1kfh, 1ik8, 1ikc, 1idi, 1idl, 2nbt – α-BGT - NMR

1bun - β2-BGT

1mr6 – γ-BGT – NMR

1kba – κ-BGT

BGT+binding peptide
1l4w, 1ljz, 1kc4, 1kl8, 1jbd, 1haa, 1haj, 1idg, 1idh, 1hoy, 1bxp, 1abt, 1rgj, 2btx – α-BGT+AChR peptide - NMR

1hc9 - α-BGT+AChR peptide

BGT+ AChR subunit
2qc1 – α-BGT+mAChR a subunit